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Nutrient ingestion increases rectal sensitivity in humans

F Musial1, M D Crowell, K T Kalveram

  • 1Department of Biological Cybernetics and Psychobiology, Heinrich-Heine University, Düsseldorf, Germany.

Physiology & Behavior
|May 1, 1994
PubMed
Summary
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Eating significantly lowers the rectal urge to defecate and pain thresholds in healthy individuals. Nutrient ingestion alters rectal sensation, indicating a postprandial effect on gut perception.

Area of Science:

  • Gastroenterology
  • Neurogastroenterology
  • Physiology

Background:

  • Nutrient ingestion is known to influence gastrointestinal motility and sensation.
  • Previous animal studies suggest a link between nutrient intake and altered rectal sensitivity.

Purpose of the Study:

  • To investigate the impact of nutrient ingestion on rectal perception thresholds in healthy human volunteers.
  • To quantify changes in the sensation of first urge, urge to defecate, and pain following a meal.

Main Methods:

  • Eight healthy volunteers underwent rectosigmoid balloon distentions using a computerized automated pump.
  • Rectal perception thresholds were measured on two separate days: a control day (no meal) and an experimental day (post-meal).
  • Threshold determinations were made before and after a 600 kcal liquid meal on the experimental day.

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Main Results:

  • Following nutrient ingestion, significant reductions were observed in the distention volumes required to elicit the urge to defecate and the pain threshold.
  • The threshold for the urge to defecate decreased by an average of -20.55% postprandially.
  • The maximum tolerable volume (pain threshold) decreased by an average of -16.09% after the meal.

Conclusions:

  • Nutrient ingestion significantly reduces rectal perception thresholds for the urge to defecate and pain in healthy individuals.
  • These findings in humans corroborate previous observations from animal studies.
  • Postprandial changes in rectal sensation highlight the complex interplay between nutrient intake and gut perception.