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Related Experiment Videos

Multiple doses of contrast medium from a single container: bacteriological studies

B M Tress1, A G Hellyar, J Pennington

  • 1University of Melbourne Department of Radiology, Royal Melbourne Hospital, Parkville, Vic., Australia.

Australasian Radiology
|May 1, 1994
PubMed
Summary
This summary is machine-generated.

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Iopromide, a non-ionic contrast medium, showed minimal bacterial growth, even with repeated use from a single bottle. Safe multi-dose use is possible with aseptic techniques, but discard unused contrast after 4 hours.

Area of Science:

  • Microbiology
  • Radiology

Background:

  • Non-ionic contrast media like Iopromide are widely used in radiology.
  • Concerns exist regarding bacterial contamination and safe multi-dose usage of contrast media.

Purpose of the Study:

  • To assess the in vitro antimicrobial properties of Iopromide.
  • To evaluate the risk of bacterial contamination in Iopromide bottles.
  • To determine safe guidelines for the multi-dose use of Iopromide.

Main Methods:

  • Inoculation of Iopromide, brain/heart infusion broth, and distilled water with Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus.
  • Incubation at 35-37°C and room temperature.
  • Monitoring bacterial counts over time.

Main Results:

Related Experiment Videos

  • Iopromide exhibited slow decreases in bacterial counts for most tested organisms.
  • Escherichia coli and Staphylococcus aureus counts stabilized in Iopromide after 6-8 hours.
  • Pseudomonas aeruginosa showed a slight increase in Iopromide at 37°C.
  • No contamination was found in repeatedly accessed Iopromide bottles.

Conclusions:

  • Iopromide demonstrates some antimicrobial activity, but is not sterile.
  • Multiple intravenous doses from a single Iopromide bottle can be safely administered with strict aseptic precautions.
  • Discard unused decanted contrast medium within 4 hours to minimize contamination risk.