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Related Experiment Videos

Immediate hypersensitivity reaction to cyclophosphamide

D J Knysak1, J A McLean, W R Solomon

  • 1University of Michigan Medical Center, Department of Internal Medicine, Ann Arbor 48109-0380.

Arthritis and Rheumatism
|July 1, 1994
PubMed
Summary
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Anaphylaxis to cyclophosphamide occurred in a lupus patient. Skin tests revealed hypersensitivity to cyclophosphamide and its metabolite, suggesting a shared antigen or dual sensitization.

Area of Science:

  • Immunology
  • Rheumatology
  • Pharmacology

Background:

  • Cyclophosphamide is an alkylating agent used in treating systemic lupus erythematosus (SLE).
  • Anaphylaxis is a severe, potentially life-threatening allergic reaction.

Observation:

  • A patient with SLE experienced an acute anaphylactic reaction following intravenous cyclophosphamide administration.
  • Skin testing was conducted on the patient and six healthy controls to assess reactivity to cyclophosphamide and its metabolite, 4-hydroperoxycyclophosphamide.

Findings:

  • The patient demonstrated positive skin test responses to both cyclophosphamide and 4-hydroperoxycyclophosphamide.
  • All control subjects exhibited negative skin test responses.

Implications:

Related Experiment Videos

  • These findings suggest the patient's anaphylaxis was an acute hypersensitivity reaction.
  • The reaction may be linked to sensitivity to cyclophosphamide and its metabolite, potentially due to a shared antigenic determinant or dual sensitization.
  • This highlights the importance of considering hypersensitivity reactions to cyclophosphamide in patients with SLE.