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Related Experiment Videos

Interactions between magnesium and iron. In vitro studies

G Disch1, H G Classen, W Haubold

  • 1Department of Pharmacology and Toxicology of Nutrition, University of Hohenheim, Stuttgart, Fed. Rep. of Germany.

Arzneimittel-Forschung
|May 1, 1994
PubMed
Summary
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Magnesium (Mg) compounds affect iron (Fe) absorption. Poorly soluble Mg oxides and trisilicates significantly reduce Fe absorption by adsorbing it, while soluble Mg aspartate hydrochloride does not interfere with Fe absorption.

Area of Science:

  • Nutritional biochemistry
  • Gastrointestinal physiology
  • Mineral interactions

Background:

  • Iron (Fe) absorption is crucial for preventing anemia.
  • Interactions between minerals, such as magnesium (Mg) and Fe, can influence nutrient bioavailability.
  • Previous literature suggests Mg may affect Fe absorption, but the mechanisms and specific Mg compounds involved require further clarification.

Purpose of the Study:

  • To investigate the in vitro effects of different magnesium (Mg) compounds on iron (Fe) absorption.
  • To determine if the solubility and chemical properties of Mg compounds influence their interaction with Fe.
  • To elucidate the impact of Mg on Fe bioavailability in a simulated gastrointestinal environment.

Main Methods:

  • In vitro experiments assessing the influence of Mg compounds on the pH of aqueous solutions.

Related Experiment Videos

  • Simulating physiological pH variations in the gastrointestinal tract.
  • Quantifying Fe and Mg content in the supernatant after co-administration of Fe and Mg salts.

    • Main Results:

    • Poorly soluble Mg compounds (Mg oxide, Mg trisilicate) significantly reduced the amount of dissolved Fe in solution.
    • Soluble Mg aspartate hydrochloride trihydrate showed minimal effect on Fe solubility.
    • Mg oxide and Mg trisilicate exhibited potent neutralizing effects on acidic solutions, while Mg aspartate hydrochloride had a slight alkaline shift.

    Conclusions:

    • Poorly soluble Mg compounds adsorb Fe, significantly interfering with Fe absorption.
    • Soluble Mg aspartate hydrochloride does not appreciably influence Fe absorption due to its minimal impact on pH.
    • The solubility and acid-neutralizing capacity of Mg compounds are key factors determining their effect on Fe bioavailability.