Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thymic education--T cells do it for themselves

T J Pawlowski1, U D Staerz

  • 1Dept of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.

Immunology Today
|May 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of anti-receptor antibodies to focus T-cell activity.

Immunology today·2014
Same author

A physiological ligand of positive selection is recognized as a weak agonist.

Journal of immunology (Baltimore, Md. : 1950)·2000
Same author

A physiological ligand of positive selection is seen with high specificity.

Journal of immunology (Baltimore, Md. : 1950)·2000
Same author

Induction of specific immune tolerance with hybrid antibodies.

Immunology today·2000
Same author

Liposome encapsulated aurothiomalate reduces collagen-induced arthritis in DBA/1J mice.

Biochimica et biophysica acta·1999
Same author

Treatment of an autoimmune disease with "classical" T cell veto: a proposal.

Journal of clinical immunology·1999
Same journal

Foreword.

Immunology today·2020
Same journal

The origin and significance of anti-DNA antibodies.

Immunology today·2014
Same journal

Mutations of class II MHC molecules.

Immunology today·2014
Same journal

Antigen processing at the molecular level.

Immunology today·2014
Same journal

Phenotypically and functionally distinct T-cell subsets in anti-tumor responses.

Immunology today·2014
Same journal

Are MHC class II-restricted cytotoxic T lymphocytes important?

Immunology today·2014
See all related articles

Positive selection of T cells is known, but the cells selecting the restriction element remain unclear. New evidence suggests non-epithelial or non-hematopoietic cells can also select the restriction element for alpha beta T-cell receptor T cells.

Area of Science:

  • Immunology
  • T cell biology
  • Cellular interactions

Background:

  • Positive selection of developing T cells is a critical process in adaptive immunity.
  • The specific cellular interactions mediating the selection of the T cell receptor (TCR) restriction element are not fully understood.
  • Traditionally, epithelial and hematopoietic cells have been considered the primary mediators of this selection process.

Purpose of the Study:

  • To review recent advancements in understanding T cell positive selection.
  • To present novel evidence regarding the cellular origins involved in TCR restriction element selection.
  • To challenge the established view on the exclusive role of epithelial and hematopoietic cells in T cell selection.

Main Methods:

  • Review of current literature on T cell positive selection.

Related Experiment Videos

  • Discussion of emerging experimental data.
  • Analysis of T cell-restricted antigen presentation.

    • Main Results:

    • Established knowledge on T cell positive selection is confirmed.
    • New findings indicate that cells beyond epithelial or hematopoietic origins can select the TCR restriction element.
    • This broadens the scope of cells involved in shaping the T cell repertoire.

    Conclusions:

    • The cellular basis for T cell restriction element selection is more diverse than previously thought.
    • Non-traditional cell types may play significant roles in T cell development.
    • Further research is needed to fully elucidate the mechanisms and implications of these diverse cellular interactions in T cell selection.