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Crosstalk in the mouse thymus
W van Ewijk1, E W Shores, A Singer
1Dept of Immunology, Erasmus University, Rotterdam, The Netherlands.
Immunology Today
|May 1, 1994
Abstract:
The development of mature T cells within the thymus is dependent upon intact cortical and medullary microenvironments. In turn, thymic microenvironments themselves are dependent on lymphoid cells to maintain their integrity. Here, Willem van Ewijk and colleagues discuss experiments that have established the phenomenon of 'crosstalk' within the mouse thymus and suggest a mechanism whereby lymphoid and stromal cells influence each other in a consecutive manner during T-cell development.