Transcription factor nuclear factor I proteins form stable homo- and heterodimers
1Institut für Biologie III/Genetik, Albert-Ludwigs-Universität, Freiburg, Germany.
Abstract:
Nuclear factor I (NFI) proteins constitute a large family of eukaryotic DNA binding proteins. They are involved in viral and cellular aspects of transcriptional regulation and they are capable of stimulating adenovirus initiation of replication. Using in vitro translated NFI proteins encoded by four different chicken NFI genes, we have detected homodimers as well as heterodimers for all combinations tested. The formation of heterodimers was critically dependent on cotranslation, indicating stable dimer formation in the absence of DNA. The unrestricted heterodimerization of NFI proteins adds, beside gene diversity and alternative splicing, another level of diversity to this protein family.
More Related Videos
Related Concept Videos
Transcription Factors
Transcription Factors
Cooperative Binding of Transcription Regulators
General Transcription Factors
Cooperative Binding of Transcription Regulators
Transducer Mechanism: Nuclear Receptors
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:


