Melanoma: 2. Diagnosis and treatment

The tumors can progress rapidly from superficial lesions of the epidermis, which are nearly all curable by excision, to invasive cancers unresponsive to current therapy. New strategies for regional and systemic spread include multiagent chemotherapy combined with biologic response modifiers, such as alpha-interferon or interleukin-2. On the early evidence, some of these approaches are promising.