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Obstructive jaundice impairs reticuloendothelial function and promotes bacterial translocation in the rat
J W Ding1, R Andersson, V Soltesz
1Department of Surgery, Lund University Hospital, Sweden.
The Journal of Surgical Research
|August 1, 1994
Summary
Obstructive jaundice impairs the reticuloendothelial system (RES) function and increases bacterial translocation in rats. This may explain why jaundiced patients are susceptible to sepsis and kidney problems after surgery.
Area of Science:
- Hepatology and Immunology
- Surgical Pathophysiology
Background:
- Obstructive jaundice is linked to increased sepsis and renal insufficiency post-biliary surgery.
- The underlying mechanisms for this heightened susceptibility remain unclear.
Purpose of the Study:
- To investigate how biliary obstruction affects reticuloendothelial system (RES) function.
- To assess the impact of biliary obstruction on bacterial translocation in a rat model.
Main Methods:
- Rats underwent either sham operation or common bile duct ligation (CBDL).
- RES function was measured by clearance of 125I-labeled Escherichia coli.
- Bacterial translocation was assessed at 3 days, 1, 2, and 3 weeks post-procedure.
Main Results:
- Jaundiced rats showed significantly impaired RES function and increased renal uptake of E. coli from Day 3 onwards.
- Elevated plasma bilirubin and liver enzymes were observed in jaundiced rats.
- Bacterial translocation incidence significantly increased at 3 days, 1 week, and 2 weeks after CBDL.
Conclusions:
- Biliary obstruction in rats leads to impaired RES phagocytic activity.
- Increased bacterial translocation is a consequence of obstructive jaundice.
- These findings offer insights into the susceptibility of jaundiced patients to postoperative sepsis and renal dysfunction.