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Related Experiment Videos

[Multiple drug resistance]

I Svoboda-Beusan1

  • 1Imunoloski zavod, Zagreb.

Lijecnicki Vjesnik
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Multidrug resistance (MDR) in cells involves cross-resistance to diverse drugs, often due to altered plasma membranes. Overexpressed P-glycoprotein (Pgp) is linked to this complex MDR phenotype.

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Area of Science:

  • Cellular Biology
  • Pharmacology
  • Biochemistry

Context:

  • Mammalian cell lines exhibit complex multidrug resistance (MDR).
  • Acquired cross-resistance to structurally dissimilar drugs is a hallmark of MDR.
  • This phenomenon is often linked to alterations in the cell's plasma membrane.

Purpose:

  • To review the current understanding of multidrug resistance (MDR).
  • To explore the etiology, pathogenesis, diagnosis, and therapy of MDR.
  • To discuss the role of P-glycoprotein (Pgp) in mediating MDR.

Summary:

  • Multidrug resistance (MDR) involves acquiring resistance to a wide array of drugs lacking structural similarities.
  • A key feature of MDR is decreased net cellular drug accumulation, attributed to plasma membrane changes.

Related Experiment Videos

  • Overexpression of P-glycoprotein (Pgp), a 170 kD plasma membrane protein, is consistently observed in MDR cells and tumors, suggesting its role in mediating MDR.

    • Impact:

    • Provides a comprehensive overview of MDR, aiding researchers and clinicians.
    • Highlights the central role of P-glycoprotein (Pgp) in MDR.
    • Informs potential therapeutic strategies targeting MDR mechanisms.