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Tay-Sachs disease: high gene frequency in a non-Jewish population
T E Kelly1, G A Chase, M M Kaback
1Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
American Journal of Human Genetics
|May 1, 1975
Abstract:
A non-Amish "Pennsylvania Dutch" semi-isolate was found to have a high frequency of Tay-Sachs gene. This high frequency could be ascribed to founder effect and may represent, in microcosm, how this mechanism could have produced the high gene frequency among Ashkenazi Jews.