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Related Experiment Videos

Evaluation of myocardial function

K E Jochim1, D M Behrendt

  • 1Department of Physiology, University of Michigan Medical School, Ann Arbor.

The Annals of Thoracic Surgery
|July 1, 1975
PubMed
Summary
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Assessing myocardial contractility involves various indices, but none are perfect. Controlling preload, afterload, and heart rate is crucial for valid measurements of heart muscle function.

Area of Science:

  • Cardiology
  • Physiology

Background:

  • Myocardial contractility assessment can be performed on isolated muscle, whole hearts, or in intact patients.
  • Numerous indices exist, but each has limitations and is not entirely independent of influencing factors.

Purpose of the Study:

  • To review and discuss various indices used for assessing myocardial contractility.
  • To highlight the importance of controlling preload, afterload, and heart rate for accurate measurements.

Main Methods:

  • Review of existing literature on myocardial contractility assessment.
  • Discussion of different indices and their relationship to preload, afterload, and heart rate.

Main Results:

  • Indices of contractility include those reflecting isometric contraction (e.g., pressure change rate) and ejection phenomena (e.g., ejection fraction).

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  • No single index is perfect, and all are influenced by preload, afterload, and heart rate.

    • Conclusions:

    • Accurate assessment of myocardial contractility requires careful control of preload, afterload, and heart rate.
    • Many clinical studies on myocardial function lack validity due to failure to control these critical variables.