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Pharmacokinetics of dideoxyinosine in neonatal pigtailed macaques
C M Pereira1, C Nosbisch, J D Unadkat
1Department of Pharmaceutics, University of Washington, Seattle 98195.
Antimicrobial Agents and Chemotherapy
|April 1, 1994
Abstract:
To determine whether age affects the pharmacokinetics of dideoxyinosine in neonatal pigtailed macaques (Macaca nemestrina), dideoxyinosine (10 mg/kg of body weight) was administered as a single intravenous bolus to macaques at ages < 1 week, 1 month, and 4 months. Clearance from plasma at < 1 week of age was significantly lower (P < 0.05) and the terminal half-life was significantly higher than the corresponding values obtained at 1 month and 4 months of age. Our data indicate that the pharmacokinetics of dideoxyinosine change significantly with age in M. nemestrina.