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Role of DNA methylation in the regulation of transcription
1Department of Cellular Biochemistry, Hebrew University, Hadassah Medical School, Jerusalem, Israel.
Current Opinion in Genetics & Development
|April 1, 1994
Abstract:
DNA methylation plays an important role in the regulation of gene expression during development. Methyl moieties at CpG residues suppress transcription by affecting DNA-protein interactions, thus altering the accessibility of genes to trans-acting factors in the cell. Because it works in cis, this mechanism is important in the control of X inactivation and genomic imprinting.