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Internuclear ophthalmoplegia in sickle cell trait
1Department of Ophthalmology, George Washington University Medical Center, Washington, D.C.
Summary
Sickle cell trait, though uncommon, can cause brainstem infarction leading to internuclear ophthalmoplegia in children. This case highlights the importance of considering sickle cell trait in pediatric neurological presentations.
Area of Science:
- Neurology
- Pediatrics
- Hematology
Background:
- Internuclear ophthalmoplegia is a neurological condition affecting eye movement coordination.
- Brainstem infarction can manifest with various neurological deficits.
Observation:
- An 8-year-old boy presented with symptoms suggestive of right internuclear ophthalmoplegia.
- Neuroimaging revealed a high-intensity signal in the medial longitudinal fasciculus on T2-weighted MRI.
Findings:
- Laboratory tests confirmed the presence of sickle cell trait.
- Sickle cell trait was identified as an unusual etiology for the observed brainstem infarction.
Implications:
- This case underscores the need to consider sickle cell trait in the differential diagnosis of pediatric brainstem infarction.
- Early identification and management of sickle cell trait can prevent severe neurological complications.