[Effect of lipid peroxidation injury to endothelial cells (EC) on adherence of monocytes]

Inducing lipid peroxidation injury to cultured EC from human umbilical vein was achieved by treating EC with diamide. When the concentration of diamide reached 0.1 x 10(-4) mol/l, intracellular accumulation of lipid peroxide and EC damage were induced and then increased adherence of monocyte to EC was observed. Monocytes appeared to prefer to adhere onto the surfaces and intercellular spaces of the injured EC. These results suggest that the increased adherence of monocytes to EC injured by lipid peroxidation may play an important role in atherogenesis.