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Relationship between subjective effects and drug preferences: ethanol and diazepam
1University of Chicago Department of Psychiatry, IL 60637.
Drug and Alcohol Dependence
|February 1, 1994
Summary
Understanding drug preference is key. This study found that subjective effects and demographics like gender influence choices for ethanol and diazepam in normal volunteers.
Area of Science:
- Psychopharmacology
- Behavioral Neuroscience
Background:
- Individual differences in drug response are significant.
- Understanding factors influencing drug preference is crucial for addiction research.
Purpose of the Study:
- To meta-analyze the relationship between subjective drug effects and drug preference.
- To compare 'choosers' and 'non-choosers' based on drug responses and demographics.
Main Methods:
- Meta-analysis of published studies using a choice procedure for ethanol and diazepam versus placebo.
- Subjective effects and demographic variables were analyzed in relation to drug choice.
Main Results:
- Ethanol's effects differed: decreased positive mood in non-choosers, increased arousal in choosers. Ethanol choosers were more likely male students.
- Diazepam decreased anxiety and increased friendliness in choosers. Diazepam choice correlated with recreational stimulant and marijuana use.
- Both subjective experiences and demographic factors influenced drug preference.
Conclusions:
- Subjective drug effects and demographic variables are associated with drug preference.
- Findings highlight individual variability in drug response and choice.
- This research contributes to understanding the neurobiological and social factors in drug preference.