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How many embryos should be transferred in in vitro fertilization? A prospective randomized study
D Vauthier-Brouzes1, G Lefebvre, S Lesourd
1Département de Gynécologie Obstétrique, Centre Hospitalo Universitaire Pitié Salpétrière, Paris, France.
Fertility and Sterility
|August 1, 1994
Summary
Transferring two fresh embryos during in vitro fertilization (IVF) maintains pregnancy rates while significantly reducing high-order multiple pregnancies in selected women. This approach optimizes IVF success and safety.
Area of Science:
- Reproductive Medicine
- In Vitro Fertilization (IVF)
Background:
- High-order multiple pregnancies are a significant risk associated with IVF.
- Selecting suitable candidates for IVF is crucial for optimizing outcomes.
Purpose of the Study:
- To assess the impact of limiting fresh embryo transfer on pregnancy and multiple pregnancy rates in selected IVF patients.
- To determine if transferring fewer fresh embryos can maintain pregnancy success while reducing high-rank multiples.
Main Methods:
- A prospective, randomized study involving 56 couples undergoing IVF.
- Participants were women ≤35 years with ≥70% cleavage rate and ≥4 regular embryos.
- Two groups were compared: four fresh embryo transfer (FET) vs. two FET with two frozen for later transfer.
Main Results:
- The overall pregnancy rate was comparable between the two groups.
- High-rank multiple pregnancies occurred in one-third of the four-FET group, with none in the two-FET group.
- Freezing surplus embryos did not negatively impact pregnancy rates.
Conclusions:
- Transferring only two fresh embryos is sufficient for achieving pregnancy in selected IVF populations.
- This strategy effectively suppresses high-rank multiple pregnancies, improving IVF safety and outcomes.