Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exogenous endophthalmitis initially treated without systemic antibiotics

P R Pavan1, E E Oteiza, B A Hughes

  • 1University of South Florida College of Medicine, Tampa 33612-4799.

Ophthalmology
|July 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

When the body speaks during wartime: Clinical presentation of older vs. younger adults in psychiatric emergencies during wartime.

The American journal of emergency medicine·2026
Same author

Adapting to the digital age in psychiatry: evaluating change in emergency department nurses and psychiatrists' views toward telepsychiatry for involuntary hospitalization.

Frontiers in digital health·2026
Same author

The distinctive P450 oxidoreductase (PORD) urinary steroid metabolome in the first week of life: Report of three cases with severe disorder.

The Journal of steroid biochemistry and molecular biology·2025
Same author

Plastic physicians: The surgical salamanders of the COVID-19 pandemic.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2020
Same author

Response to - 'Managing hand trauma during the COVID-19 pandemic using a one-stop clinic'.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2020
Same author

The use of Whatsapp<sup>Ⓡ</sup> as a way to deliver plastic surgery teaching during the COVID-19 pandemic.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2020

Intravitreal antibiotics alone are effective for bacterial endophthalmitis unless infection spreads beyond the eye. Systemic antibiotics are reserved for cases with orbital cellulitis or other severe complications.

Area of Science:

  • Ophthalmology
  • Infectious Diseases

Background:

  • Acute exogenous bacterial endophthalmitis is a severe intraocular infection.
  • Previous studies suggested intravitreal antibiotics alone could be effective.

Purpose of the Study:

  • To evaluate the continued reasonableness of using only intravitreal antibiotics for bacterial endophthalmitis.
  • To assess outcomes in patients treated with and without systemic antibiotics.

Main Methods:

  • Retrospective review of culture-proven bacterial endophthalmitis cases.
  • Analysis of treatment strategies: intravitreal antibiotics only versus combined intravitreal and systemic antibiotics.
  • Correlation of treatment with clinical outcomes and presence of extraocular extension.

Main Results:

Related Experiment Videos

  • Most patients treated with intravitreal antibiotics alone achieved good visual outcomes.
  • A small subset required systemic antibiotics due to complications like orbital cellulitis or infectious scleritis.
  • Common causative organisms included Staphylococcus and Gram-negative bacilli.

Conclusions:

  • Intravitreal antibiotics without systemic administration are a reasonable primary treatment for bacterial endophthalmitis.
  • Systemic antibiotics are indicated when there is evidence or high risk of infection spreading beyond the eye.
  • Signs of extraocular extension include fever, elevated white blood cell count, and anterior segment/orbital involvement.