[A case of Waldenstrom's macroglobulinemia complicated by diabetes insipidus]

A case of monoclonal plasma-cell dyscrasia with marked spleen and liver enlargement, though without adenopathy, is described. A diagnosis of primary macrocryogelglobulinaemia was reached following immunoelectrophoresis, immunodiffusion, analytic ultracentrifugation and immunofluorescence. Splenectomy was performed to relieve compression disturbances. Four months after surgery, diabetes insipidus began. This was probably caused by the paraprotidopoietic neoplastic proliferation of Waldenström's disease, its effect being felt the sites of ADH production.