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[The blocking effect of hyperin on the inward flow of calcium ion]
Insights
Hyperin inhibits the positive inotropic action of calcium ions by reducing calcium influx. This natural compound affects myocardial cell action potentials, indicating its potential role in cardiovascular research.
Area of Science:
- Pharmacology
- Cardiovascular Physiology
- Biochemistry
Abstract:
Hyperin(Hyp) was shown to inhibit the positive inotropic action of calcium ion on the isolated papillary muscles and shift the dose response curve of calcium ion to the right. As a plot lg(x-1) vs -lg(B) resulted in straight lines with slopes of -0.625. On the action potentials of guinea pig myocardial cells, Hyp markedly decreased the duration of plateau of action potentials (APD20%) but did not influence the APD100%, RP, APA, OS and Vmax. In the atrium preparations of mice, Hyp significantly inhibited influx of 45Ca induced by high K+. All findings indicate that Hyp can inhibit the inward flow of calcium ion.