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An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
00:06

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Published on: September 12, 2019

Recent advances and controversies in the management of Hodgkin's disease

P H O'Brien, K Wallace, V B Rambo

    Surgery, Gynecology & Obstetrics
    |March 1, 1975
    PubMed

    Insights

    For Hodgkin

    Area of Science:

    • Oncology
    • Hematology

    Background:

    • Hodgkin's disease staging is critical for treatment planning.
    • Laparotomy and splenectomy have been debated as staging procedures.

    Purpose of the Study:

    • To define criteria for the appropriate use of laparotomy and splenectomy in Hodgkin's disease staging.
    • To provide guidelines for radiation therapy in Hodgkin's disease.

    Main Methods:

    • Review of factors influencing the decision for surgical staging.
    • Analysis of clinical staging protocols.
    • Recommendations for radiation therapy parameters.

    Main Results:

    • Laparotomy and splenectomy are recommended for clinical Stages I-III and unconfirmed Stage IV Hodgkin's disease in specialized centers.
    • Subdiaphragmatic irradiation should be based on confirmed disease presence.
    • A minimum of 4,000 rads is recommended for involved areas and adjacent lymph nodes.

    Conclusions:

    • Confirmation of diagnosis and histologic classification by a hematologic pathologist is essential.
    • Comprehensive clinical staging, excluding lymphangiography, should be performed.
    • Selective use of laparotomy, splenectomy, and total nodal irradiation is advocated based on disease extent and contraindications.

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