Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polyhydroxy-mediated interactions between liposomes and bacterial biofilms

M N Jones1, M Kaszuba

  • 1School of Biological Sciences, Division of Biochemistry and Molecular Biology, University of Manchester, UK.

Biochimica Et Biophysica Acta
|July 13, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Esophageal varices during pregnancy in the course of cirrhosis.

European review for medical and pharmacological sciences·2020
Same author

Measuring disorganized speech in schizophrenia: automated analysis explains variance in cognitive deficits beyond clinician-rated scales.

Psychological medicine·2018
Same author

[Pathological travel in a population of migrants: A retrospective study].

L'Encephale·2017
Same author

[Risk assessment of developing aggressive behavior].

Revue medicale de Bruxelles·2012
Same author

The use of lectins for liposome targeting in drug delivery.

Methods in molecular medicine·2011
Same author

Cold machine perfusion versus static cold storage of kidneys donated after cardiac death: a UK multicenter randomized controlled trial.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2010

A new model explains how bacterial surface polymers interact with liposomes. Optimal liposome adsorption to bacteria occurs at specific phosphatidylinositol (PI) concentrations, driven by subtle energy changes.

Area of Science:

  • Biophysics
  • Surface Chemistry
  • Microbiology

Background:

  • Bacterial glycocalyx polymers interact with liposomes.
  • Liposomes with polyhydroxy headgroups, like phosphatidylinositol (PI), are relevant for these interactions.

Purpose of the Study:

  • To develop a theoretical model for bacterial glycocalyx and liposome surface interactions.
  • To understand the role of polyhydroxy lipids in liposome-bacterial adhesion.

Main Methods:

  • A lattice model was used to derive equations for interaction potential energy.
  • The model considers the separation distance between bacterial and liposomal surfaces.

Main Results:

  • Small interaction energies (e.g., hydrogen bonds) can overcome classical repulsive and attractive forces.

Related Experiment Videos

  • An optimal PI concentration in liposomes maximizes liposome-bacterium adsorption potential.
  • Model predictions align with experimental findings on liposome adsorption to bacterial biofilms.

    • Conclusions:

    • Subtle changes in liposomal and bacterial surface composition significantly impact interaction dynamics.
    • The theoretical model provides a framework for understanding and optimizing liposome-bacterial interactions.