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Lipomembranous (membranocystic) changes associated with morphea: a clinicopathologic review of three cases
1Department of Dermatology, Mayo Clinic, Rochester, MN 55905.
Journal of the American Academy of Dermatology
|August 1, 1994
Abstract:
Lipomembranous (membranocystic) changes represent a distinctive form of pathology in adipose tissue. Although first described in the rare neurodegenerative disorder now called Nasu-Hakola disease, this change has also been observed in a variety of relatively common inflammatory and noninflammatory dermatoses. We report three cases of morphea associated with marked lipomembranous (membranocystic) changes in the subcutaneous adipose tissue.
Insights
Lipomembranous changes, a rare adipose tissue pathology, were observed in three morphea cases. This finding links this distinctive change to morphea, a common skin condition.
Area of Science:
- Adipose tissue pathology
- Dermatology
- Histopathology
Background:
- Lipomembranous (membranocystic) changes are a specific finding in adipose tissue.
- These changes were initially identified in Nasu-Hakola disease.
- They have also been noted in various inflammatory and noninflammatory dermatoses.
Observation:
- Three cases of morphea were studied.
- These cases exhibited significant lipomembranous (membranocystic) changes.
- The changes were located in the subcutaneous adipose tissue.
Findings:
- Morphea, a localized scleroderma, is associated with lipomembranous changes in subcutaneous fat.
- This study highlights a previously under-recognized histopathological finding in morphea.
Implications:
- The findings suggest a potential link between morphea and lipomembranous changes.
- Further research may elucidate the role of these changes in morphea pathogenesis.
- This association could inform diagnostic and therapeutic strategies for morphea.