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Granuloma annulare: an immunohistochemical study
1Department of Medicine, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey 17033.
Journal of Cutaneous Pathology
|April 1, 1994
Summary
Histiocytic markers commonly used for other granulomas did not stain the infiltrate in granuloma annulare. This suggests a unique, locally derived immune cell population drives this skin condition.
Area of Science:
- Dermatopathology
- Immunohistochemistry
- Cellular Biology
Background:
- The cellular infiltrate in granuloma annulare is not well understood.
- Monocyte/histiocytic responses are key in many granulomatous diseases but lack detailed study in granuloma annulare.
Purpose of the Study:
- To investigate the immunohistochemical profile of the infiltrate in granuloma annulare.
- To determine if commonly used histiocytic markers are effective in identifying cells within granuloma annulare lesions.
Main Methods:
- Immunohistochemical staining of granuloma annulare skin biopsy specimens.
- Utilized a panel of markers including Ham 56, KP1, factor XIIIa, Mac 387, vimentin, and lysozyme.
Main Results:
- The infiltrate in granuloma annulare did not stain with most common histiocytic markers (Ham 56, KP1, factor XIIIa, Mac 387).
- Staining was observed only with antibodies against vimentin and lysozyme, suggesting these cells are not typical histiocytes found in other granulomas.
Conclusions:
- The cellular infiltrate in granuloma annulare exhibits an atypical immunohistochemical profile.
- A hypothesis is proposed that a distinct, locally derived population of histiocytes, not recognized by standard markers, is responsible for the characteristic reaction pattern of granuloma annulare.