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Calpeptin, a calpain inhibitor, promotes neurite elongation in differentiating PC12 cells
M Pintér1, A Aszódi, P Friedrich
1Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest.
Neuroscience Letters
|March 28, 1994
Abstract:
Calpain activity of nerve growth factor (NGF)-induced rat pheochromocytoma (PC12) cells shows a transient diminution in the early phase of differentiation. Calpain activity can be further decreased by a cell-permeable calpain inhibitor, calpeptin, which enhances the effect of NGF by stimulating neurite elongation. The number of neurites sprouted by one cell is not increased by calpeptin. A possible role of calpain inhibition during PC12 cells' early differentiation is discussed.