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Emerging indications for octreotide therapy, Part 1

K W Mosdell¹, J A Visconti

¹Raabe College of Pharmacy, Ohio Northern University.

American Journal of Hospital Pharmacy

|May 1, 1994

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Octreotide, initially approved for carcinoid syndrome and vipomas, shows promise for numerous other conditions. Ongoing research suggests a broader therapeutic role for this drug, expanding its potential applications.

Area of Science:

Endocrinology
Gastroenterology
Oncology

Background:

Octreotide is FDA-approved for carcinoid syndrome and vipomas.
Accumulated research and clinical experience suggest broader therapeutic applications.
Many potential uses are based on limited studies due to condition rarity.

Purpose of the Study:

To discuss possible new indications for octreotide.
To review current research and clinical experience with octreotide.
To highlight emerging therapeutic roles for octreotide.

Main Methods:

Literature review of published research results.
Analysis of accumulated clinical experience.
Discussion of case reports and small uncontrolled studies.

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Main Results:

Octreotide is being investigated for pituitary tumors, various cancers, diabetes mellitus, and gastrointestinal disorders.
Emerging indications include psoriasis, hypercalcemia, cancer pain, PCOS, and infant hypoglycemia.
Common side effects include injection site pain and nausea; less frequent include gallstones and gastritis.

Conclusions:

Octreotide demonstrates potential for a wider range of medical conditions beyond its initial approvals.
Further well-designed trials are needed to confirm efficacy for many emerging indications.
Clinical experience continues to expand the recognized therapeutic value of octreotide.