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Use of Emla prior to circumcision
T D Puthoff1, J A Visconti, M M Tschampel
1College of Pharmacy, Ohio State University, Columbus, USA.
The Annals of Pharmacotherapy
|November 1, 1996
Summary
Emla cream is not recommended for newborn circumcision due to insufficient safety and efficacy data. Further pharmacodynamic studies are needed to evaluate its use in neonates.
Area of Science:
- Neonatal Anesthesia
- Pediatric Surgery
- Dermatology
Background:
- Emla cream (lidocaine/prilocaine) is a topical anesthetic.
- Its use for neonatal circumcision requires robust safety and efficacy data.
Purpose of the Study:
- To assess the current evidence for Emla cream's use in neonatal circumcision.
- To identify data gaps and recommend future research.
Main Methods:
- Review of existing literature on Emla cream for neonatal circumcision.
- Identification of necessary pharmacodynamic and efficacy studies.
Main Results:
- Current data are insufficient to support Emla cream for neonatal circumcision.
- No adequate safety or efficacy studies have been published.
- Ongoing pharmacodynamic studies are needed.
Conclusions:
- Routine use of Emla cream for neonatal circumcision is not recommended at this time.
- Further studies are required to establish safety, efficacy, and optimal application parameters.
- Pharmacodynamic studies assessing serum concentrations and analgesic effects are crucial.