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Emerging indications for octreotide therapy, Part 1

K W Mosdell1, J A Visconti

  • 1Raabe College of Pharmacy, Ohio Northern University.

American Journal of Hospital Pharmacy
|May 1, 1994
PubMed
Summary

Octreotide, initially approved for carcinoid syndrome and vipomas, shows promise for numerous other conditions. Ongoing research suggests a broader therapeutic role for this drug, expanding its potential applications.

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Area of Science:

  • Endocrinology
  • Gastroenterology
  • Oncology

Background:

  • Octreotide is FDA-approved for carcinoid syndrome and vipomas.
  • Accumulated research and clinical experience suggest broader therapeutic applications.
  • Many potential uses are based on limited studies due to condition rarity.

Purpose of the Study:

  • To discuss possible new indications for octreotide.
  • To review current research and clinical experience with octreotide.
  • To highlight emerging therapeutic roles for octreotide.

Main Methods:

  • Literature review of published research results.
  • Analysis of accumulated clinical experience.
  • Discussion of case reports and small uncontrolled studies.

Main Results:

  • Octreotide is being investigated for pituitary tumors, various cancers, diabetes mellitus, and gastrointestinal disorders.
  • Emerging indications include psoriasis, hypercalcemia, cancer pain, PCOS, and infant hypoglycemia.
  • Common side effects include injection site pain and nausea; less frequent include gallstones and gastritis.

Conclusions:

  • Octreotide demonstrates potential for a wider range of medical conditions beyond its initial approvals.
  • Further well-designed trials are needed to confirm efficacy for many emerging indications.
  • Clinical experience continues to expand the recognized therapeutic value of octreotide.

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