Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pattern analysis of photopatch test reactions

N J Neumann1, E Hölzle, P Lehmann

  • 1Department of Dermatology, Heinrich Heine University, Düsseldorf, Germany.

Photodermatology, Photoimmunology & Photomedicine
|April 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does SAPHO syndrome exist in dermatology?

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Pioneers in Dermatology and Venereology: an interview with Prof. Gerd Plewig.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

Investigation of gamma secretase gene complex mutations in German population with Hidradenitis suppurativa designate a complex polygenic heritage.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

Lipschütz genital ulcer revisited: is juvenile gangrenous vasculitis of the scrotum the male counterpart?

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

Isotretinoin's paradoxical effects in immortalized sebocytes.

The British journal of dermatology·2018
Same author

T helper 17 cell/regulatory T-cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities.

The British journal of dermatology·2018
Same journal

Combination Therapy With Microneedle Radiofrequency Followed by Low-Fluence 1064-Nm Picosecond Neodymium-Doped Yttrium Aluminum Garnet Laser for Melasma: A Case Series.

Photodermatology, photoimmunology & photomedicine·2026
Same journal

Primary Cutaneous CD4+ Small/Medium Sized T-Cell Lymphoproliferative Disorder Presenting in the Setting of Chronic Actinic Dermatitis.

Photodermatology, photoimmunology & photomedicine·2026
Same journal

Enhancing Photoprotection: Assessing Visible Light Photoprotection in Tinted Inorganic Sunscreens.

Photodermatology, photoimmunology & photomedicine·2026
Same journal

Combination of Oral Gliadin-Protected Superoxide Dismutase With Targeted Phototherapy in Vitiligo: A Prospective, Comparative, Randomized, Single-Blinded Study.

Photodermatology, photoimmunology & photomedicine·2026
Same journal

Exploring the Impact of Phototherapy on Cardiovascular Events and Survival in Cutaneous T-Cell Lymphoma.

Photodermatology, photoimmunology & photomedicine·2026
Same journal

Erlotinib and Leflunomide Disrupt 6-Formylindolo[3,2-b]Carbazole Metabolism and Sensitize Keratinocytes to UVA Radiation-Induced Apoptosis.

Photodermatology, photoimmunology & photomedicine·2026
See all related articles

A new computerized analysis categorizes photopatch test reactions, identifying patterns beyond classic photoallergic or phototoxic responses. This aids in understanding complex photosensitivity reactions to various substances.

Area of Science:

  • Dermatology
  • Toxicology
  • Photobiology

Background:

  • Photopatch testing is crucial for diagnosing photosensitivity reactions.
  • A significant portion of photopatch test reactions do not fit classic photoallergic or phototoxic definitions.
  • Standardized interpretation of complex photoreactions remains a challenge.

Purpose of the Study:

  • To develop a computerized analysis for interpreting unclassifiable photopatch test reactions.
  • To establish a system for categorizing photoreaction patterns based on time course and morphology.
  • To differentiate reaction patterns of various substances causing photosensitivity.

Main Methods:

  • Evaluation of over 1500 photopatch test results from a multicenter study (1985-1992).
  • Development of a computerized substance-specific reaction pattern analysis.

Related Experiment Videos

  • Sequential monitoring of reactions (immediate to 72 hours) and morphological assessment.

    • Main Results:

    • Four distinct photoreaction patterns were identified.
    • Category 1: Immediate peak, descrescendo (classic phototoxic).
    • Category 4: Delayed crescendo (classic photoallergic).
    • Categories 2 & 3: Intermediate patterns (immediate/delayed mix, plateau-like delayed) observed for disinfectants, NSAIDs, phenothiazines.
    • Systemic drugs like furosemide fit Category 1; known photoallergens like fenticlor fit Category 4.

    Conclusions:

    • The computerized analysis provides a framework for classifying diverse photopatch test reactions.
    • Categories 2 and 3 represent reaction patterns requiring further investigation into their underlying mechanisms.
    • This method enhances the diagnostic utility of photopatch testing for a wider range of photosensitizing agents.