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Abstract:
There was studied the endocrine control of the first stage of olfactory reception. In the experiments with male castration it was detected that the olfactory receptor cells had a slow tonic influence on sex steroid hormones. The most dependent on the hormone control were the olfactory cells sensitive to natural stimuli. From the morphological data it was supposed that this influence was realized through the control of process of neurogenesis of the olfactory cells. On another experimental modelestral females. Which had quick changes of sex hormone level, it was detected that the reason for the olfactory sensitivity to odor variations during estrus cycle did not localized in the peripheral part of the olfactory system. Apparently the quick endocrine influence was realized at the central part of the olfactory system.
Insights
The study reveals that sex steroid hormones influence olfactory receptor cells, particularly those sensitive to natural stimuli. This endocrine control, affecting neurogenesis, differs between slow and rapid hormonal changes.
Area of Science:
- Neuroscience
- Endocrinology
- Olfactory receptor cell biology
Context:
- Investigates the endocrine control mechanisms governing olfactory reception.
- Examines the role of sex steroid hormones in modulating olfactory sensitivity.
Purpose:
- To elucidate the influence of sex steroid hormones on olfactory receptor cells.
- To differentiate between peripheral and central mechanisms of endocrine control in olfaction.
Summary:
- Experiments with castrated males showed olfactory receptor cells exert a slow influence on sex steroid hormones, with hormone levels impacting neurogenesis of cells sensitive to natural stimuli.
- Studies on estral females revealed that rapid olfactory sensitivity changes during the estrus cycle are not due to peripheral olfactory system alterations, suggesting central nervous system involvement.
Impact:
- Highlights the intricate relationship between the endocrine system and olfactory perception.
- Suggests distinct neurogenic and central pathways for slow and rapid endocrine modulation of smell.