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Published on: February 9, 2011
Brain abscess in infants and children
Y Erşahin1, S Mutluer, E Güzelbağ
1Department of Neurosurgery, Ege University Medical School, Izmir, Turkey.
Insights
Pediatric brain abscesses are serious, with meningitis being a common cause. Mortality is higher in young children and those admitted in a coma, regardless of treatment.
Area of Science:
- Pediatric Neurosurgery
- Infectious Diseases
Background:
- Brain abscesses in children are rare but life-threatening infections.
- Understanding the causes, clinical presentation, and outcomes is crucial for effective management.
Purpose of the Study:
- To review the etiology, management, and outcomes of pediatric brain abscesses.
- To identify factors associated with mortality in this patient population.
Main Methods:
- Retrospective review of 44 pediatric patients with brain abscesses.
- Data collected on etiology, abscess characteristics, treatment modalities, and patient outcomes.
- Statistical analysis to determine factors influencing mortality.
Main Results:
- Meningitis (36%) was the leading cause, followed by otitis (27%) and head injury (16%).
- Overall mortality was 20%, with significantly higher rates in children under 2 years and those presenting in a coma.
- Surgical interventions included total excision (22), drainage (13), and needle aspiration (3).
Conclusions:
- Pediatric brain abscesses carry a significant mortality risk, particularly in younger children and those with altered consciousness.
- Early diagnosis and prompt management are essential, though etiology and specific treatment modalities did not significantly predict mortality in this series.
- Commonly isolated microorganisms included Streptococci, Staphylococci, and Proteus mirabilis.
Abstract:
Forty-four consecutive patients with brain abscesses, aged between 1 month and 16 years, were reviewed. The cause of abscess was meningitis in 36% of the cases, otitis in 27%, head injury in 16%, congenital heart disease in 9%, other in 5%, and undetected in 5%. Thirty patients had a single abscess and 12 had multiple abscesses. Multiloculated abscess was present in 2. Total excision was accomplished in 22 patients. Three patients underwent needle aspiration. Drainage of the abscess was performed in 13. Secondary excision was needed in 5 patients. One patient was treated nonsurgically. Streptococci, staphylococci and Proteus mirabilis were the microorganisms recovered in cultures. Overall mortality was 20% (9 patients). Mortality was significantly higher in patients under 2 years of age than in those older. Of 15 patients who were comatose at the time of admission, 6 died. Etiology, diagnostic method, and treatment modalities were not found to be significant factors in terms of predicting mortality.
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