[Effect of the changes of epiphysial functions on the central and peripheral immune system in mice]

Endocrine function of thymus estimated by titer of thymic serum factor is inhibited in pubertal mice CBA/Ca under conditions of pharmacological inhibition of epiphysis function by beta-adrenoblocking agent anapriline. After blinding and epithalamine and melatonine introduction the content of thymic hormone considerably increases. Melatonine is characterized by manifestation of effect in earlier periods of research. In mice with hyperfunction of epiphysis mass, cell character of thymus and spleen increase as well as the content of thymosine-like activity in supernatant of cultures of splenocytes. And on the contrary, in animals with hypofunction of epiphysis the values of studied immunological indices decrease. Immunopotentiating effect of epiphysial factors is observed not only in vivo but also in vitro and decreases in thymectomized mice. The change of the concentration of glucocorticoids in the organism is of significance in the mechanism of epiphysis effect on the immune system.