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Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives
A Stańczak1, W Kwapiszewski, A Szadowska
1Department of Pharmaceutical Chemistry and Drug Analysis, Medical University, Lódź, Poland.
Die Pharmazie
|June 1, 1994
Abstract:
Alkylation of 4-hydroxycinnolines using ethyl bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.