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Updated: Aug 20, 2026

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
Published on: October 23, 2017
[Reparative regeneration of the maxilla following osteotomy under conditions of controlled measured distraction (an
Abstract:
The authors have for the first time developed a device and created an experimental model of osteotomy in 13 adult mongrel dogs for comprehensive (radionuclide, x-ray, histologic, neutron-activation methods) investigations of the time course of reparative regeneration of maxillary laminar osseous tissue in conditions of perforating osteotomy, followed by dosed distraction (0.75 mm in 48 h by the device activation twice a day). The tension and stretching factors were found conducive to bone formation in the laminar osseous tissue. Based on these data, new osteotomy methods may be developed and the existent ones improved, as well as the methods for the treatment of patients with facial bone defects and deformations, based on the distraction methods of treatment.

