[Inhibitory effect of antimicrobial antibodies on the generalization of wound infection]

The antibody titer in wound and burn patients has been subjected to agglutination test to reveal bacterial autostrains. The antibodies to blood--isolated autostrains were shown to be present in lower titer, but more often they weren't found at all. At the clinical manifestation of sepsis the pathogenic strain (uniformly present in wound and secondary focuses, agglutinated by patient's serum in higher titer) hasn't been detected in blood. The authors conclude that the bacterial invasion of blood and generalization of infection occurs in the very first days following the emergence of bacteria in primary focus, when the antibodies to these bacteria haven't arisen yet and these is no clinical evidence of sepsis due to the small amount of those bacteria in primary focus. At the clinical manifestation of sepsis there is scant likelihood that the pathogen might be isolated from blood, occasional strains with no antibodies, may, however, be encountered.