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Neural crest cell formation and migration in the developing embryo

M Bronner-Fraser1

  • 1Developmental Biology Center, University of California, Irvine 92717.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|July 1, 1994
PubMed
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Neural crest cells migrate segmentally, influenced by embryonic tissues like somites. Molecular cues and integrin receptors likely guide this crucial developmental process.

Area of Science:

  • Developmental biology
  • Cell migration
  • Embryogenesis

Background:

  • Neural crest cells originate from the neural tube and differentiate into diverse cell types, including the peripheral nervous system, facial skeleton, and pigment cells.
  • Distinct neural crest populations exhibit unique migratory pathways and derivative ranges along the embryonic axis.
  • Midbrain neural crest cells migrate uniformly, contrasting with the segmented migration of hindbrain and trunk neural crest cells.

Purpose of the Study:

  • To investigate the migratory patterns of neural crest cells.
  • To understand the influence of embryonic tissues on neural crest cell migration.
  • To explore the molecular mechanisms underlying neural crest cell migration.

Main Methods:

  • Observational studies of neural crest cell migration in embryos.

Related Experiment Videos

  • Analysis of gene expression patterns in the hindbrain.
  • Investigation of integrin receptor roles in cell-extracellular matrix interactions.

    • Main Results:

    • Trunk neural crest cells exhibit segmental migration, favoring the rostral half of somites.
    • Mesodermal somites and the otic placode significantly influence neural crest cell migration patterns.
    • Gene expression in the hindbrain and integrin receptors are implicated in regulating neural crest cell migration.

    Conclusions:

    • Embryonic tissue interactions are critical for directing segmental neural crest cell migration.
    • Molecular factors, including gene expression and integrin signaling, play a key role in neural crest cell guidance.
    • Further research into the molecular basis of neural crest cell migration is warranted.