Related Experiment Videos
Pancreas transplantation and dysuria
E A Elkhammas1, M L Henry, J P York
1Department of Surgery, Ohio State University, Columbus.
The Journal of Urology
|September 1, 1994
Summary
Bladder drainage in pancreas transplants is common but can cause urological issues. Early intervention for the dysuria syndrome, possibly due to pancreatic enzymes, is recommended for successful patient outcomes.
Area of Science:
- Urology
- Transplantation Surgery
- Nephrology
Background:
- Bladder drainage is the standard technique for pancreatic grafts, offering superior survival rates compared to other methods.
- Despite its efficacy, bladder drainage is associated with significant urological complications.
- Combined kidney/pancreas transplantation is a common procedure where this drainage technique is employed.
Observation:
- Six cases of dysuria syndrome were observed following combined kidney/pancreas transplantation.
- Patients presented with symptoms indicative of a urological complication post-transplant.
- The study investigated the specific nature and cause of these post-transplant urological issues.
Findings:
- Retrograde urethrography or cystoscopy revealed urethral extravasation in all affected patients.
- Activated proteolytic exocrine enzymes from the transplanted pancreas are the suspected cause of the observed extravasation.
- Minor urethral trauma from catheterization or cystoscopy may act as a predisposing factor.
Implications:
- The dysuria syndrome is a recognized complication of pancreatic graft bladder drainage.
- Prompt diagnosis and management, including short-term catheterization, can effectively resolve the condition.
- Maintaining a high index of suspicion and early intervention are crucial for managing patients experiencing dysuria syndrome post-transplant.