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Updated: Aug 16, 2026

Single-molecule Super-resolution Imaging of Phosphatidylinositol 4,5-bisphosphate in the Plasma Membrane with Novel Fluorescent Probes
Published on: October 15, 2016
Functional specialization of the glycosylphosphatidylinositol membrane anchor
1Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas 75235.
Abstract:
The discovery of GPI-anchored membrane proteins presented a conundrum for membrane biologists. What could the special purpose be for this type of membrane anchor and why couldn't a transmembrane anchor do the same job? Recent information from several different sources is beginning to provide answers to these questions. In this review, evidence is presented that GPI-anchored membrane proteins are uniquely adapted for delivering to the cell both nutrient and signaling molecules or ions using two distinct endocytic pathways. So far, they are the only surface molecules known to have this capability.
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