[Microcirculatory changes during the long-term course of deafferentation pain syndrome]

It was shown that during 5 months after section of the sciatic nerve in 100% of rats the extremity's autotomies took place. In clinic development of deafferentation pain syndrome the waves character of autotomy was previal (86%); the maximal waves during 6 month was 6. In 14% of animals it was shown the deafferentation pain syndrome with permanent autotomy. The disorders of terminal blood flow, increase venular permeability and mast cells degranulation was shown in rats with hard autotomy. The microcirculation disturbances increased in case of autotomy repeated. The recovery of extremities with autotomy correlated with normalization of microcirculation. The microcirculation disorders (stasis) and degranulation of the mast cells were hard in rats with permanent autotomy then in rats with repeated autotomy.