[The formation of a pathological system in rats with neuropathic trigeminal neuralgia]

The intensity of clinical manifestations (rubbing of the oro-facial area with skin injury), bioelectric activity of the somatosensory cortex and microcirculatory disturbances were studied for 6 weeks in Wistar rats with partial infraorbital nerve compression. These parameters were compared among rats of the following groups: without skin rubbing (1), with them (2), with repaired skin (3) after nerve compression and sham-operated rats (4). A correlation between the intensity of clinical manifestations and microcirculatory disturbances was shown. Epileptiform cortex activity was observed in 100% and 75% rats of the 2nd and 3rd groups, respectively, while in group 1 this per cent decreased time. These results are discussed with regard to the formation of pathologic algic system which underlies the pain syndrome and affects peripheral target organs.