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Respiratory virus infection of mice provokes a permanent humoral immune response
L Hyland1, M Sangster, R Sealy
1Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101.
Journal of Virology
|September 1, 1994
Abstract:
We have observed that respiratory virus infection of mice provokes an extremely persistent humoral immune reaction, due to a long-sustained population of antibody-secreting cells in the bone marrow. Theories of humoral immunity that strongly distinguish primary and secondary reactions thus may not adequately describe the immune response to respiratory viruses.