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Exercise-induced asthma--clinical, physiological, and therapeutic implications
The Journal of Allergy and Clinical Immunology
|July 1, 1975
Summary
Exercise-induced asthma (EIA) causes airway obstruction after exercise, varying by activity type and intensity. Medications like bronchodilators and cromolyn sodium can prevent EIA, making exercise testing valuable for asthma research.
Area of Science:
- Pulmonology
- Exercise Physiology
- Pharmacology
Background:
- Exercise is a common trigger for acute airways obstruction in asthma patients.
- The severity of exercise-induced asthma (EIA) varies significantly with exercise type, duration, and intensity.
- EIA is not caused by hyperventilation or blood gas alterations but by the release of short-lived mediators.
Purpose of the Study:
- To investigate the factors influencing exercise-induced asthma (EIA).
- To evaluate the efficacy of various pharmacological interventions in preventing EIA.
- To establish exercise testing as a standardized model for studying asthma physiology and pharmacology.
Main Methods:
- Comparing EIA severity across different exercise modalities (running, cycling, swimming, walking).
- Assessing the impact of exercise duration and intensity on EIA.
- Evaluating the preventative effects of bronchodilators, sympathomimetics, cromolyn sodium, atropine, alpha-adrenergic blockers, and steroids on EIA.
Main Results:
- Running elicits the most severe EIA, while swimming and walking cause the least.
- Maximum EIA occurs after 6-8 minutes of intense exercise (HR 180 bpm in children, 140 bpm in adults).
- Bronchodilators, sympathomimetics, and cromolyn sodium effectively prevent EIA; other agents show variable efficacy.
Conclusions:
- Exercise testing is a valuable, standardized model for studying asthma.
- Understanding EIA triggers and effective preventions aids in asthma management and prognosis.
- Pharmacological interventions, particularly bronchodilators and cromolyn sodium, are key in managing EIA.
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