Related Experiment Videos
Retinal toxicity of intravitreally injected faeriefungin
W A Dunlap1, M Karaçorlu, G A Peyman
1LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans 70112-2234.
Ophthalmic Surgery
|May 1, 1994
Summary
Faeriefungin, a novel antibacterial and antifungal agent, showed no retinal toxicity in rabbits at doses of 100 micrograms or less. Higher doses caused moderate to severe retinal toxicity, suggesting a safe therapeutic window for treating eye infections.
Area of Science:
- Microbiology
- Ophthalmology
- Pharmacology
Background:
- Faeriefungin is a new antibacterial and antifungal agent.
- It is derived from Streptomyces griseus var. autotrophicus.
Purpose of the Study:
- To assess the retinal toxicity of faeriefungin.
- To determine the safety of faeriefungin for potential use in treating endophthalmitis.
Main Methods:
- Intravitreal injections of varying faeriefungin concentrations (10-400 micrograms) were administered to albino rabbits.
- Retinal toxicity was evaluated using electroretinography and light and transmission electron microscopy.
Main Results:
- Severe retinal toxicity was observed at 400 micrograms of faeriefungin.
- Moderate toxicity was noted at 200 micrograms.
- No neuroretinal toxicity was detected at concentrations of 100 micrograms or less.
Conclusions:
- Faeriefungin demonstrates a dose-dependent retinal toxicity profile.
- Concentrations of 100 micrograms or less appear safe for intravitreal use.
- Faeriefungin shows potential as a therapeutic agent for bacterial or fungal endophthalmitis.