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Hemoperfusion in chronic uremia

S Stefoni1, G Feliciangeli, G Cianciolo

  • 1Nephrology Department, S. Orsola Hospital, Bologna.

Bollettino Della Societa Italiana Di Biologia Sperimentale
|November 1, 1993
PubMed
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A novel anionic exchange resin effectively removes phosphates during hemoperfusion, demonstrating satisfactory phosphate clearance and biocompatibility in animal models. This blood purification technique shows promise for managing phosphate levels.

Area of Science:

  • Nephrology
  • Biomaterials Science
  • Extracorporeal Therapies

Background:

  • Hemoperfusion is a blood purification method using direct blood-sorbent contact.
  • Existing sorbents include activated charcoal, immunoadsorbents, and resins.
  • Previous research focused on charcoal hemoperfusion.

Purpose of the Study:

  • To evaluate a new coated anionic exchange resin for phosphate removal during hemoperfusion.
  • To assess the efficacy and biocompatibility of this novel resin in an animal model.

Main Methods:

  • Surgically induced uremia in 3 pigs.
  • Six extracorporeal hemoperfusion sessions using a cartridge with 100g of the resin.
  • Measurement of phosphate clearance and monitoring of blood parameters (pH, bicarbonate).

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Main Results:

  • Satisfactory phosphate clearance was achieved, with values of 120 ml/min at 10 minutes and approximately 80 ml/min after 2 hours.
  • The resin and its coating membrane exhibited satisfactory biocompatibility.
  • Negligible variations in pH and plasma bicarbonate indicated minimal absorption of competing blood anions.

Conclusions:

  • The tested anionic exchange resin is effective for phosphate removal in hemoperfusion.
  • The resin demonstrates good biocompatibility and selectivity for phosphate.
  • This hemoperfusion approach shows potential for managing phosphate levels in uremic conditions.