The echocardiographic assessment of the human fetal foramen ovale

The foramen ovale size and interatrial flow patterns were studied by combined real-time and Doppler echocardiography in 100 normal human fetuses between 20 and 38 weeks gestation. The foramen ovale, atrioventricular, and semilunar valve diameters increased linearly with gestational age. The foramen flap motion and interatrial flow patterns showed biphasic flow patterns with interatrial flow reversal with atrial systole. Color flow mapping of the diameter of the interatrial flow profile showed good correlation with the foramen ovale size as measured by two-dimensional echocardiography. These data represent the first large study of the normal human foramen ovale correlated with gestational age, thus expanding the reference base for ultrasound assessment of fetal heart.