Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vasculitis in rheumatoid arthritis

J J Goronzy1, C M Weyand

  • 1Mayo Clinic and Foundation, Division of Rheumatology, Rochester, MN 55905.

Current Opinion in Rheumatology
|May 1, 1994
PubMed
Summary

Rheumatoid vasculitis may be a distinct aspect of rheumatoid arthritis, separate from joint inflammation. This suggests patients may have either joint-only disease or joint and systemic disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The life cycle of a T cell after vaccination - where does immune ageing strike?

Clinical and experimental immunology·2016
Same author

Activated human T cells express alternative mRNA transcripts encoding a secreted form of RANKL.

Genes and immunity·2013
Same author

Altered naive and memory CD4+ T-cell homeostasis and immunosenescence characterize younger patients with myelodysplastic syndrome.

Leukemia·2009
Same author

[Pathogenesis of medium- and large-vessel vasculitis].

Zeitschrift fur Rheumatologie·2009
Same author

Immune-mediated mechanisms in atherosclerosis: prevention and treatment of clinical manifestations.

Current pharmaceutical design·2008
Same author

VEGF gene polymorphisms and susceptibility to rheumatoid arthritis.

Rheumatology (Oxford, England)·2004

Area of Science:

  • Rheumatology
  • Immunology
  • Pathogenesis of Autoimmune Diseases

Background:

  • Rheumatoid arthritis (RA) primarily affects the synovial membrane.
  • A subset of RA patients develop rheumatoid vasculitis, an inflammatory destruction of blood vessels.
  • Traditionally, rheumatoid vasculitis is considered a severe manifestation of RA extending beyond joints, potentially due to immune complex deposition.

Purpose of the Study:

  • To propose and support an alternative pathogenetic model for rheumatoid vasculitis.
  • To differentiate RA patients into distinct groups based on disease involvement (synovial vs. synovial plus extra-articular).

Main Methods:

  • Immunogenetic analysis, specifically examining HLA-DRB1*0401 homozygosity.
  • Clinical observation of disease clustering and correlation between synovial and extra-articular disease activity.

Main Results:

  • A higher prevalence of rheumatoid vasculitis was observed in RA patients who were HLA-DRB1*0401 homozygotes.
  • Clinical data suggests that different types of extra-articular manifestations cluster in certain patients.
  • The activity of synovial disease did not correlate with the activity of extra-articular disease.

Conclusions:

  • Rheumatoid vasculitis may represent a distinct dimension of rheumatoid disease, not solely a complication of severe joint inflammation.
  • RA patients can potentially be categorized into those with synovial disease only and those with both synovial and extra-articular disease.
  • Immunogenetic and clinical findings support a model where rheumatoid vasculitis is a separate entity within the spectrum of rheumatoid disease.

Related Experiment Videos