Jove
Visualize
Contact Us

Related Experiment Videos

Update on therapy for precocious puberty

M D Wheeler1

  • 1Department of Pediatrics, University of Arizona, Tucson.

Comprehensive Therapy
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Precocious puberty, early onset of puberty before age 8/9, has central or peripheral causes. Treatment depends on etiology, with GnRH-agonists for central and other agents for peripheral types.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A disposable chemical heater and dry enzyme preparation for lysis and extraction of DNA and RNA from microorganisms.

Analytical methods : advancing methods and applications·2023
Same author

Gene and antisense delivery in alcoholism research.

Alcoholism, clinical and experimental research·2002
Same author

Endothelial cells contain a glycine-gated chloride channel.

Nutrition and cancer·2002
Same author

Viral gene delivery of superoxide dismutase attenuates experimental cholestasis-induced liver fibrosis in the rat.

Gene therapy·2002
Same author

Comparison of the effect of adenoviral delivery of three superoxide dismutase genes against hepatic ischemia-reperfusion injury.

Human gene therapy·2002
Same author

The role of Kupffer cell oxidant production in early ethanol-induced liver disease.

Free radical biology & medicine·2001
Same journal

Heparin-induced thrombocytopenia and thrombosis.

Comprehensive therapy·2011
Same journal

Antiplatelet therapy in cardiovascular disease.

Comprehensive therapy·2011
Same journal

Genetics of cardiovascular disease.

Comprehensive therapy·2011
Same journal

Septic renal vein thrombosis complicated by septic pulmonary embolism.

Comprehensive therapy·2011
Same journal

Gout and hyperuricemia.

Comprehensive therapy·2011
Same journal

Problems with computerized health records.

Comprehensive therapy·2011
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Pediatric Endocrinology
  • Reproductive Medicine
  • Hormone Therapy

Background:

  • Precocious puberty is defined as pubertal development before age 8 years in girls and 9 years in boys.
  • Causes are classified as central (CPP) or peripheral (PPP).
  • Both types lead to rapid growth and skeletal advancement, potentially resulting in shorter adult stature due to early epiphyseal fusion.

Purpose of the Study:

  • To review the classification and management of precocious puberty.
  • To differentiate therapeutic strategies for central versus peripheral precocious puberty.

Main Methods:

  • Classification of precocious puberty based on etiology (central vs. peripheral).
  • Review of therapeutic options for each subtype.
  • Discussion of hormonal and physical characteristics.

Related Experiment Videos

Main Results:

  • Central precocious puberty (CPP) involves premature hypothalamic-pituitary axis activation.
  • Peripheral precocious puberty (PPP) results from sex steroid production independent of the hypothalamic-pituitary axis.
  • Long-acting GnRH-agonists are effective for CPP, while other agents manage PPP.

Conclusions:

  • Therapy for precocious puberty must be tailored to the underlying cause.
  • GnRH-agonists offer effective, reversible treatment for CPP.
  • Management of PPP involves agents like testolactone, spironolactone, or ketoconazole.