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Updated: Sep 2, 2026

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
Published on: July 1, 2020
Surface hydrophobicity enhances corticosterone incorporation in Candida albicans
1Department of Biology, Fairfield University, Connecticut 06430.
Abstract:
Increased intracellular incorporation of [3H]corticosterone in Candida albicans was dependent on cell surface hydrophobicity. C. albicans strains were grown in culture conditions that induced surface hydrophobicity, and cell wall conditions were evaluated with a polystyrene microsphere assay. Germ tubes, which exhibited the greatest cell surface hydrophobicity, incorporated seven times more radiolabel than the hydrophilic yeast forms. Hydrophobic yeasts contained four times more [3H]corticosterone than their polar counterparts. Hydrophobic yeasts incubated for 48 h on nutrient agar containing corticosterone showed reduced colony size compared with controls. These results demonstrate that environmental factors which augment cell wall hydrophobicity in C. albicans can increase the incorporation of corticosterone, which may influence the metabolic activities in this organism.
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