Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A flexible random allocation program for multi-institutional clinical trials

T Odaka1, K Akazawa, Y Watanabe

  • 1Department of Information Science, Faculty of Engineering, Fukui University.

Journal of Medical Systems
|February 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy and safety of anticoagulant therapy in three specific populations with sepsis: a meta-analysis of randomized controlled trials.

Journal of thrombosis and haemostasis : JTH·2015
Same author

Recombinant human soluble thrombomodulin in severe sepsis: a systematic review and meta-analysis.

Journal of thrombosis and haemostasis : JTH·2015
Same author

Field performance and cytology of protoplast-derived rice (Oryza sativa): high yield and low degree of variation of four japonica cultivars.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
Same author

Communicating by electrolarynx with a blind tetraplegic spinal cord injury patient on mechanical ventilation in the ICU.

Spinal cord·2013
Same author

Time-resolved optical mammography and its preliminary clinical results.

Technology in cancer research & treatment·2011
Same author

Interleukin-1β causes long-term potentiation deficiency in a mouse model of septic encephalopathy.

Neuroscience·2011

This study introduces a flexible random allocation program for multi-institutional clinical trials. It efficiently assigns treatments based on prognostic factors, optimizing patient group balance.

Area of Science:

  • Clinical Trials Methodology
  • Biostatistics
  • Health Informatics

Background:

  • Randomization is crucial for unbiased clinical trials.
  • Multi-institutional trials require robust allocation methods to balance patient groups.
  • Existing methods may lack flexibility in handling multiple prognostic factors and institutions.

Purpose of the Study:

  • To present a flexible random allocation program for multi-institutional clinical trials.
  • To describe a program that assigns treatments based on prognostic factors.
  • To detail methods for balancing institutions and treatments.

Main Methods:

  • The program utilizes Pocock and Simon's minimization method.
  • Zelen's method is incorporated for institution balancing.

Related Experiment Videos

  • The system allows arbitrary settings for institutions, treatments, and prognostic factors.

    • Main Results:

    • The program demonstrates flexibility in accommodating varying numbers of parameters.
    • It is limited only by computer main memory size.
    • An example shows capacity for 1500 institutions, 4 treatments, and 20 factors on an IBM-PC.

    Conclusions:

    • The developed program offers a flexible and efficient solution for complex clinical trial randomization.
    • It supports the balanced allocation of treatments considering multiple prognostic factors across institutions.
    • The software is adaptable to diverse trial designs and resource constraints.